Hello Montdor,
Thank you for using Apple Support Communities. Sounds like you’re trying to use the three finger tap gesture to use the “Look up and data detectors” feature with your Mac, but nothing happens. You also mentioned that this issue continues in safe mode. According to the following resource here: How to use safe mode on your Mac - Apple Support
It states the following:
If the issue continues in safe mode
If the issue continues while in safe mode, or your Mac restarts several times and then shuts down while starting up in safe mode, you should reinstall macOS and make sure that your Apple software and third-party apps are up to date.
The resource suggests for you to perform a macOS reinstall. Steps for that can be found here: How to reinstall macOS - Apple Support
Apple silicon
Turn on your Mac and continue to press and hold the power button until you see the startup options window. Click the gear icon labeled Options, then click Continue. If you're asked to select a user you know the password for, select the user, click Next, then enter their administrator password.
Once you see these options, select Reinstall macOS Ventura.
Feel free to keep us posted on your results. Thank you for using Apple Support Communities.