Macos Sequoia 15.0 and office 365 - not responding

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This worked for me: Open the Terminal and run the following commands:

enter below 2 lines and click enter

/System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/LaunchServices.framework/Versions/A/Support/lsregister -kill -r -domain local -domain system -domain user 

Now enter below 2 lines and click enter, Let it run 2 mins and quit terminal it will fix issue

sudo /System/Library/Frameworks/CoreServices.framework/Frameworks/LaunchServices.framework/Support/lsregister -kill -seed -lint -r -f -v -dump -domain local -domain system -domain user -domain network

How I Fixed It

Since upgrading to macOS Sequoia (15.0.1), I’ve been facing issues with Microsoft Office 365 (version 16.89). Every time I tried opening a Word, Excel, the application wouldn’t respond, forcing me to quit and restart it. After reinstalling Office multiple times without any luck, I finally found a solution: resetting macOS to factory settings.

To fix the issue, I went to Settings > General > Transfer or Reset, and did a full reset. After that, Office 365 began working as expected, allowing me to open and work on files without freezing.

This process solved the problem for me, so if anyone else is facing similar issues, it might be worth a try!

The 15.01 did not fix the issues

Same problem here--on Office for Mac Version 16.89.1 and just upgraded for Sequoia 15.0. I get the spinning pinwheel when I try to open Word and PPT files. No difference if I open from the Finder or Word or PPT itself. Then have to force quit the Finder and/or Word or PPT and try again. Eventually it works but I cannot determine why or why not. Really frustrating as this is a basic function.

I have two laptops, a MacBook Pro M1 2021 and a MacBook Air M1 2020. Both have been upgraded to macOS Sequoia. While the Microsoft apps work perfectly on the MacBook Pro, they are completely unresponsive on the MacBook Air. I’ve tried deleting and reinstalling the apps twice, but the issue persists. It’s very frustrating.

Not a problem with office 365 freezing but I am getting a lot more Excel errors stating it's "...run out of resources while attempting to calculate one of more formulas...." on spreadsheets that worked fine prior to the Sequoia release. This on an M2 Air with 24GB RAM

But the issue is persisting with the 15.0 stable release. The only thing that makes Office 365 (web) manageable is using the 'icon' view, everything else is just a blank page. Constant reloading after I click a link to open the link.

It is only an issue in Safari for me. Using Office 365 (web) with Firefox, everything works fine.

[Edited by Moderator]

This worked for me: Open the Terminal and run the following commands:

/System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/LaunchServices.framework/Versions/A/Support/lsregister -kill -r -domain local -domain system -domain user 

sudo /System/Library/Frameworks/CoreServices.framework/Frameworks/LaunchServices.framework/Support/lsregister -kill -seed -lint -r -f -v -dump -domain local -domain system -domain user -domain network

Safari v18, definitely "breaks" O365 online...on the other hand, Teams online, has been in "Preview" mode for Safari, for years, many years.???

Oddly, Google's online app get along well with Sequoia / Safari 18.???

Microsoft is pushing Microsoft Edge, Bing and Copilot...coincidence? If you want seamless compatibility with O365 online, use Microsoft's Edge browser.

Same problem. I was fine until I installed the .0.1 version.

However, I did set up a new user account and everything is fine there, so I wonder if it really is a general compatibility issue with Sequoia/O365 or some file or process that wasn't replicated when I created the new user.

Thanks, but a lot of us have tried this without success.

Similarly for the suggestion to do a factory reset - like setting up a new user account but even more of a pain eg what do you restore from - if it's a Time Machine backup you run the risk of reinstalling the same problem since no-one seems to know what causes the problem.

I'm not familiar enough with Terminal so can someone tell me if running these commands could also affect the new user account I set up where I'm not having the same problem? I'd hate to do this only to discover that one had somehow got "infected" too.

And are these separate commands to be run sequentially or do I just paste the entire set into Terminal?

Thanks

I understand your concern. In my case, I didn’t restore any files from Time Machine for exactly that reason — I didn’t want to risk reinstalling the same issue. Fortunately, all my Word documents were already saved in OneDrive, so I didn’t lose any data. As for the apps, I reinstalled everything from scratch, which seemed to prevent any old issues from reappearing. It’s definitely a bit of a hassle, but in my situation, it was worth it since Office 365 started working properly again after the reset.

I tried running those Terminal commands, but unfortunately, they didn’t work for me. The issue persisted, and I still had to go through the factory reset to get Office 365 to function properly. Thanks for the suggestion, though!