The operation can’t be completed because an unexpected error occurred (error code -50).

What were you doing when you received this error?

Did you do anything before the error occurred?

Try booting to Safe Mode. That boot up takes minutes and clears caches and other things that may resolve your problem.

How to use safe mode on your Mac - Apple Support

A lot of times just boot to Safe Mode followed by normal boot resolves problems.

This sounds a bit similar to the error 60 code that I was recently getting from the Disk Utility (when creating a large disk image from a source folder on an external SDD). In my case, the remedy was to erase and then recreate the APFS Container (including 2 volumes, one configured as a Time Machine volume).

Is this a New Issue ? If Yes, what exactly changed on this computer ?

Is this an Old Issue ? If Yes, what actions has the user taken to fix this issue ?

Details and context will really help to pinpoint possible solutions.