Based on a quick review of your EtreCheck report:
Short version: you’ve got a perfect storm of I/O stalls + legacy audio/USB cruft + disabled security, and it’s tipping macOS into a userspace-watchdog panic. The panic you captured (“no successful checkins from logd in 120 seconds”) is classic when storage or low-level drivers wedge the system. Your EtreCheck shows a filesystem call that literally timed out (120.55 s), heavy Photos background indexing (photoanalysisd/photolibraryd), Backblaze activity, and a pile of old audio kexts (Soundflower, iShowU, RemotePCSound, ACE) plus USB hubs/devices. That cocktail, together with unsigned/system mods and translocated apps (Hej Stylus), explains the beachballs, WindowServer/bluetoothd crashes, and the panic.
I’d also flag software hygiene: automatic and security updates are disabled, hosts file is heavily modified, and there’s “AntiCC [HCiSO]” on the install list. Aside from the obvious risk, those tools often patch services that touch login/windowing and networking, and they regularly break notarization/Gatekeeper paths—exactly the kind of thing that shows up here as “Unsigned files / Apple security disabled.” Finally, storage: your NVMe 980 PRO is fast on reads, but the timed-out filesystem call plus constant Photos/Backblaze churn suggest periodic I/O hiccups. The secondary SATA BX500 (HFS+, no TRIM) is another likely source of stalls if any libraries live there.