What Mac's will work best with Eizo RX250 ports?

The Eizo Radiforce RX250 is a 21.3" display with an IPS panel, and a native resolution of 1200 x 1600 pixels.

It has the following ports:

• A DVI-D input that might be limited to signals with 8-bit-per-channel color
• A DisplayPort input that can accept signals with 10-bit-per-channel color
• A DisplayPort output port for daisy-chaining (which Macs do not support)
• An upstream USB-B (USB 2.0) port and two downstream USB-A (USB 2.0) ports

So far, so good. I would think that you could connect it to a new Mac in several ways, e.g.,

• USB-C to DisplayPort adapter cable
• HDMI cable + HDMI to DVI-D adapter (on Macs with HDMI ports, like the Mac mini and MacBook Pro)

The only reason I can think of to go from HDMI to DVI-D would be to save a USB-C / Thunderbolt port, since the monitor's DisplayPort input is more modern and might also be more functional.

The specifications contain the phrase "from a palette of 543 billion (13-bit) colors" and mention a utility disk with "RadCS LE" (whatever that is). Eizo has their manuals behind a "you must be a registered user" wall, so I am not able to skim the manuals. However, I suspect that this monitor supports hardware calibration.

So the compatibility question is more likely to revolve around software than around hardware.

• If the display supports hardware calibration (where the calibration settings are stored in the monitor), is there software (either from Eizo or from someone else) that is compatible with current Macs and whatever hardware calibration device you are using, and that can calibrate this display?
• Since this display is targeted at the medical imaging market, is the medical software that you're using – which generates the images to display on the monitor – compatible with current Macs?

The first question might be one for Eizo or for the vendor of whatever calibration tool you are using. The second question would be one for your medical application supplier(s).

That would be a question for the manufacturer.