Why does my Mac mini wake up every few minutes?

I have a problem with my Mac Mini. At night, I put the Mac in sleep mode, but every 4-5 minutes, the connected peripherals wake up, only to go back to sleep after a few minutes. I have an SSD connected to the USB port, and it keeps turning on and off because the Mac repeatedly suspends and reactivates it. In the morning, when I wake up, the SSD is very hot as it has spent the entire night turning on and off due to the Mac. Is there a way to put the peripherals to sleep without them being reactivated every 5 minutes? This doesn’t seem like normal behavior.

[Re-Titled by Moderator]