Junk Mail Explosion

Recently, my Junk Mail folder gets a very high number (hundreds) of messages daily. This is unexplainable and now it's more difficult to set rules and filters because apparently the spammers are using AI to generate random "from" addresses and infinite variations on subject lines in the e-mails. I continually block senders, only to be thwarted by the algorithms that generate these nuisance messages. Does anyone have any novel strategies besides continuing to add rules and block senders that could provide some relief from these attacks on e-mail? Thanks in advance for any advice or techniques.