Thank you, CedricNguyen, for your reply, and added info!
Re: the pdf is blank again after I edited
About iPadOS 16 Updates - Apple Support
says: the most recent is PadOS 16.3.1
May be good to update and see if there's any improvement.
(If you do have that version already:
maybe try re-starting your iPad: Restart your iPad - Apple Support
(ie: If something is not working right, restarting will often put things back in order.)
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Re: the pdf is blank again after I edited
Wondering how you are editing the original PDF
Eg : in Read PDF documents in Books on iPad – Apple Support
says: Mark up a PDF:
Open the PDF and tap
to use the drawing and annotation tools
(tap near the center of a page if you don’t see
).
If needed:
More info. on using Markup:
Draw in apps with Markup on iPad – Apple Support
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Re: does the heavy file have impact on this? Because my pdf file is 293mb
That is a hefty file! Sorry, I don't know for sure.
(Wouldn't think so, as the Books app handles and annotates books.)
Wondering how you are saving the file after editing.
Seems Apple is now often using the "Share" button to export / save files in apps