iCloud drive on removable drives...

I am the happy owner of a new Mac mini M2 pro, after 23 years of Mac ownership I am very happy with it (other than the fact that there is a WIFI bug that I hope Apple will resolve soon!).

The mini has a 500Gb hard drive, as such I have another hard drive also connected by USB 4 that is 1TB.

My question, is can I put secondary files that I don't access regularly on the removable hard drive but still sync with iCloud Drive?

Currently all my iCloud Drive files are syncing to my first hard drive but I don't want this to happen as I will be out of memory quickly?

I hope that this makes sense, I like the iCloud Drive, but I wish to have the option to place sync files on secondary devices?