Screenshot is not letting me choose clipboard as the save location

FWIW, I just had a closer look at your screen shot. You have "Record Entire Screen" selected. You can't copy a video recording to the Clipboard. That's why it's not in the list.

AnthonyMacUser1 wrote:

I used to be able to select clipboard as the save location but it is not showing, why? How do I fix it?

You should still see Clipboard as an option…

Try booting into Safe Mode, then restart normally.

How to use safe mode on your Mac - Apple Support

Take a screenshot on your Mac

Where to find screenshots

By default, screenshots save to your desktop with the name ”Screen Shot [date] at [time].png.”

In macOS Mojave or later, you can change the default location of saved screenshots from the Options menu in the Screenshot app. You can also drag the thumbnail to a folder or document.

See the following from Take a screenshot on your Mac - Apple Support

To copy a screenshot to the Clipboard, press and hold the Control key while you take the screenshot.