All external Hard drive not working in normal mode but in safe mode on my MacBook

you have installed and re-installed and re-installed a vast amount of junk.

In this context, “junk" is like stuff in your attic  -- it may be perfectly good, but is not needed right now.

By far the easiest way to cause poor performance, instability, overheating and crashing is to install ANY third-party speeder-uppers, Cleaners, Optimizers, or Virus scanners, Bit Torrent, or a VPN that you installed yourself.

The idea that a third party, with no special knowledge of the inner workings of MacOS, can somehow find a simple way to protect or speed up your computer — that is not already being done by MacOS itself — suggests that the MacOS developers are somehow "holding out on you". That is absurd.

the first to go needs to be Crowdstrike. It is interfering with the mac's Built-in virus protection.

You have Apple managed clients active AND Jamf installed and have installed a small fleet of MDM restriction profiles. if they is your doing, you need to back that stuff out and get rid of it.

You have installed some stuff from snow software that is not signed. All modern legitimate software for Mac should be signed, and anything that is not signed with a developer certificate has no place on a modern Mac. you should remove that stuff right away. the cloud metering and scan result portion are flagged as potential malware.

¿What is the date of your most recent backup, and by what method?