Ventura 13.6.3 says 'Your system has run out of application memory'

There are 2 reasons for the “Your system has run out of application memory” dialog box.

A. Your boot disk has very low free storage, and macOS cannot create page/swap files to offload virtual memory contents to disk. Depending on how much virtual memory is being called for, anything under 50-100GB of free storage may trigger the message.

Apple menu (upper left corner) -> About This Mac -> Storage (tab)

B. A process (or set of processes) has asked macOS for excessive amounts of virtual memory address space. In order to keep track of the virtual memory address space, the kernel creates virtual memory page tables. If there is a memory leak (process asks for a virtual address range, forgets to give it back, asks for another range, forgets again, wash, rinse, repeat), eventually there are so many page tables created there is no memory left for applications, and you get the “Your system has run out of applications memory”.

Look at

Applications -> Utilities -> Activity Monitor -> View (menu) -> All Processes -> Memory (tab)

you can see what processes are using lots of memory. Many of these processes will be background agents and daemons used to provide many of the macOS services, as well as your applications.

Also keep in mind that each web browser tab will be a separate process running its own Javascript. If you have lots of browser tabs open, or if one of the browser tabs running Javascript with a bug in it, it is possible these browser tabs will add up to a lot of virtual memory demands, but no individual tab will look all that big.

Use the Activity Monitor application and make sure to use View >> View All Processes 

What process or processes are using the Most CPU and Memory ?

Often times - the issue maybe not a single Process alone but a combination of Processes

Also, when the computer is using so much CPU / Memory - it can be an indicator of a Lack Of Empty Space on the Drive.

In which case, the CPU and Memory usage would become much more because it is searching for Empty Space to save all the Changes the user is performing.

It can also be , it depends on the number of  Open Tabs in your Browser, they can also affect CPU / Memory Usage.

Me too. When I use the Xcode, My Mac often crashes and restarts because of this process. Too many times. 😤️

MacOS Monterey 12.7.2

MacBook Pro (13-inch, 2017, Two Thunderbolt 3 ports)

2.3 GHz Dual-Core Intel Core i5

8 GB 2133 MHz LPDDR3

Intel Iris Plus Graphics 640 1536 MB

panic(cpu 0 caller 0xffffff7fb08e2503): "Submission on work queue 36 failed due to insufficient space!\n" @IGGuC.cpp:2899
Panicked task 0xffffff90351d2380: 6 threads: pid 5994: SimMetalHost
Backtrace (CPU 0), panicked thread: 0xffffff8b5e8cdaa0, Frame : Return Address
0xffffffe559f3ae00 : 0xffffff8018279a3d 
0xffffffe559f3ae50 : 0xffffff80183dca26 
0xffffffe559f3ae90 : 0xffffff80183cbd93 
0xffffffe559f3aee0 : 0xffffff8018219a90 
0xffffffe559f3af00 : 0xffffff8018279e0d 
0xffffffe559f3b020 : 0xffffff80182795c6 
0xffffffe559f3b080 : 0xffffff8018b149d3 
0xffffffe559f3b170 : 0xffffff7fb08e2503 
0xffffffe559f3b180 : 0xffffff7fb0859b3b 
0xffffffe559f3b270 : 0xffffff7fb087f688 
0xffffffe559f3b2a0 : 0xffffff7fb086c934 
0xffffffe559f3b360 : 0xffffff7fb0867a31 
0xffffffe559f3b3d0 : 0xffffff7fb08967ba 
0xffffffe559f3b5e0 : 0xffffff7fb086bd18 
0xffffffe559f3b620 : 0xffffff7fb11e6118 
0xffffffe559f3b650 : 0xffffff7fb086b944 
0xffffffe559f3b690 : 0xffffff7fb11e62a7 
0xffffffe559f3b6d0 : 0xffffff7fb11e6996 
0xffffffe559f3b970 : 0xffffff7fb086c338 
0xffffffe559f3b9a0 : 0xffffff7fb11e78f1 
0xffffffe559f3ba30 : 0xffffff7fb11e594b 
0xffffffe559f3ba90 : 0xffffff7fb11e5741 
0xffffffe559f3bae0 : 0xffffff7fb11e481d 
0xffffffe559f3bb20 : 0xffffff7fb086bf7b 
0xffffffe559f3bb60 : 0xffffff8018a8319c 
0xffffffe559f3bcc0 : 0xffffff8018382746 
0xffffffe559f3bdd0 : 0xffffff80182544cb 
0xffffffe559f3be60 : 0xffffff801826ae49 
0xffffffe559f3bef0 : 0xffffff80183aea5a 
0xffffffe559f3bfa0 : 0xffffff801821a276 
      Kernel Extensions in backtrace:
         com.apple.iokit.IOAcceleratorFamily2(462.9)[18935109-D234-37EF-8E5A-3F4477072221]@0xffffff7fb119f000->0xffffff7fb1209fff
            dependency: com.apple.driver.AppleMobileFileIntegrity(1.0.5)[744F1519-535C-37DB-B1F5-B48D9AD7F6F2]@0xffffff80199b1000->0xffffff80199d3fff
            dependency: com.apple.iokit.IOGraphicsFamily(597)[DE5041AE-9925-3C33-8EA8-31084CD1C0EB]@0xffffff7fb1338000->0xffffff7fb1366fff
            dependency: com.apple.iokit.IOPCIFamily(2.9)[116B27E9-BAAB-34E5-87E5-E7D14B436CBF]@0xffffff801ae37000->0xffffff801ae63fff
            dependency: com.apple.iokit.IOReportFamily(47)[8A41F1B1-06E0-346E-9FF8-CC8DD9E63C19]@0xffffff801ae75000->0xffffff801ae77fff
            dependency: com.apple.iokit.IOSurface(302.15)[F0C45899-50E7-3036-9766-01061C67C399]@0xffffff801afaa000->0xffffff801afc6fff
         com.apple.driver.AppleIntelKBLGraphics(18.0.8)[88ABE530-D7BA-34AF-B075-5D0632EFE2F7]@0xffffff7fb0854000->0xffffff7fb0912fff
            dependency: com.apple.iokit.IOAcceleratorFamily2(462.9)[18935109-D234-37EF-8E5A-3F4477072221]@0xffffff7fb119f000->0xffffff7fb1209fff
            dependency: com.apple.iokit.IOGraphicsFamily(597)[DE5041AE-9925-3C33-8EA8-31084CD1C0EB]@0xffffff7fb1338000->0xffffff7fb1366fff
            dependency: com.apple.iokit.IOPCIFamily(2.9)[116B27E9-BAAB-34E5-87E5-E7D14B436CBF]@0xffffff801ae37000->0xffffff801ae63fff
            dependency: com.apple.iokit.IOSurface(302.15)[F0C45899-50E7-3036-9766-01061C67C399]@0xffffff801afaa000->0xffffff801afc6fff

Process name corresponding to current thread (0xffffff8b5e8cdaa0): SimMetalHost (iPhone 12: default

Mac OS version:
21G1974

👍

Much better and detailed trouble shooting suggestions 😎