Most likely the hard drive is failing, but if you want to confirm this run DriveDx and post the report here using the "Additional Text" icon which looks like a piece of paper.
The EtreCheck report also shows you using almost 2GB of Swap which usually indicates you are running low on memory. You can try closing other apps when you are using a memory intensive app. Whenever Swap is used items in the fast memory are moved to the extremely slow hard drive which most likely is even slower than usual because it is worn out or failing. Replacing the hard drive with an SSD can help with the Swap performance, but it may not be enough without replacing one of the 4GB memory modules with an 8GB module for a total of 12GB of memory. Only use memory from Crucial or OWC since Macs are very particular about the memory they use. Even then make sure to only order the exact part number suggested by the tools on their respective websites.
Google Chrome is also known to be CPU and memory intensive. I've also seen some reports that some cloud syncing sites may cause system slowness as well due to how they implement their file syncing, but I'm not sure which ones are guilty of this.
The "Service Battery" condition indicates that macOS has detected a hardware fault with the battery.